Penetration of cefuroxime into ventricular fluid in cerebrospinal fluid shunt infections

M. S. Edwards, C. J. Baker, K. M. Butler, Edward Mason, J. P. Laurent, W. R. Cheek

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h intervals. Levels of cefuroxime in ventricular fluid ranged from 1.6 to 22.5 μg/ml and were associated with cerebrospinal fluid bactericidal titers ranging from less than 1:2 to 1:16 against infecting staphylococcal isolates. Five infections were cured with cefuroxime monotherapy. On the basis of MIC data, one patient had vancomycin substituted for cefuroxime and the infection was cured.

Original languageEnglish (US)
Pages (from-to)1108-1110
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume33
Issue number7
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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