Penetration of cefuroxime into ventricular fluid in cerebrospinal fluid shunt infections

M. S. Edwards, C. J. Baker, K. M. Butler, Edward Mason, J. P. Laurent, W. R. Cheek

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    The penetration of intravenously administered cefuroxime into ventricular fluid was assessed in five pediatric patients with ventriculoperitoneal shunt infections and in one with a ventriculostomy infection. Patients received a total dose of 200 to 230 mg of cefuroxime per kg of body weight per day administered at 8-h intervals. Levels of cefuroxime in ventricular fluid ranged from 1.6 to 22.5 μg/ml and were associated with cerebrospinal fluid bactericidal titers ranging from less than 1:2 to 1:16 against infecting staphylococcal isolates. Five infections were cured with cefuroxime monotherapy. On the basis of MIC data, one patient had vancomycin substituted for cefuroxime and the infection was cured.

    Original languageEnglish (US)
    Pages (from-to)1108-1110
    Number of pages3
    JournalAntimicrobial Agents and Chemotherapy
    Volume33
    Issue number7
    DOIs
    StatePublished - 1989

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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