PCSK9 Inhibitors in the Management of Cardiovascular Risk: A Practical Guidance

Xiaoming Jia; Mahmoud Al Rifai; Anum Saeed; Christie M. Ballantyne; Salim S. Virani

doi:10.2147/VHRM.S275739

PCSK9 Inhibitors in the Management of Cardiovascular Risk: A Practical Guidance

Xiaoming Jia, Mahmoud Al Rifai, Anum Saeed, Christie M. Ballantyne, Salim S. Virani

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent medications in the toolkit for treatment of atherosclerotic cardiovascular disease. These agents have been well studied in clinical trials supporting their efficacy in dramatically reducing low-density lipoprotein cholesterol (LDL-C) and impact on cardiovascular outcomes. Since the approval of commercial use for PCSK9 inhibitors in 2015, we have also gained significant experience in the use of these therapeutics in the real-world setting. In this article, we review current guideline recommendations, clinical trial evidence on efficacy and safety as well as data on cost-effectiveness, prescription and adherence. We focus primarily on the monoclonal antibody class of PCSK9 inhibitors in this review while also touching on other types of therapeutics that are under development.

Original language	English (US)
Pages (from-to)	555-566
Number of pages	12
Journal	Vascular Health and Risk Management
Volume	18
DOIs	https://doi.org/10.2147/VHRM.S275739
State	Published - 2022

Keywords

CVD prevention
lipids
PCSK9 inhibitor

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Hematology
Public Health, Environmental and Occupational Health
Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.2147/VHRM.S275739

Cite this

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title = "PCSK9 Inhibitors in the Management of Cardiovascular Risk: A Practical Guidance",

abstract = "Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent medications in the toolkit for treatment of atherosclerotic cardiovascular disease. These agents have been well studied in clinical trials supporting their efficacy in dramatically reducing low-density lipoprotein cholesterol (LDL-C) and impact on cardiovascular outcomes. Since the approval of commercial use for PCSK9 inhibitors in 2015, we have also gained significant experience in the use of these therapeutics in the real-world setting. In this article, we review current guideline recommendations, clinical trial evidence on efficacy and safety as well as data on cost-effectiveness, prescription and adherence. We focus primarily on the monoclonal antibody class of PCSK9 inhibitors in this review while also touching on other types of therapeutics that are under development.",

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author = "Xiaoming Jia and {Al Rifai}, Mahmoud and Anum Saeed and Ballantyne, {Christie M.} and Virani, {Salim S.}",

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year = "2022",

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language = "English (US)",

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AU - Jia, Xiaoming

AU - Al Rifai, Mahmoud

AU - Saeed, Anum

AU - Ballantyne, Christie M.

AU - Virani, Salim S.

PY - 2022

Y1 - 2022

N2 - Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent medications in the toolkit for treatment of atherosclerotic cardiovascular disease. These agents have been well studied in clinical trials supporting their efficacy in dramatically reducing low-density lipoprotein cholesterol (LDL-C) and impact on cardiovascular outcomes. Since the approval of commercial use for PCSK9 inhibitors in 2015, we have also gained significant experience in the use of these therapeutics in the real-world setting. In this article, we review current guideline recommendations, clinical trial evidence on efficacy and safety as well as data on cost-effectiveness, prescription and adherence. We focus primarily on the monoclonal antibody class of PCSK9 inhibitors in this review while also touching on other types of therapeutics that are under development.

AB - Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent medications in the toolkit for treatment of atherosclerotic cardiovascular disease. These agents have been well studied in clinical trials supporting their efficacy in dramatically reducing low-density lipoprotein cholesterol (LDL-C) and impact on cardiovascular outcomes. Since the approval of commercial use for PCSK9 inhibitors in 2015, we have also gained significant experience in the use of these therapeutics in the real-world setting. In this article, we review current guideline recommendations, clinical trial evidence on efficacy and safety as well as data on cost-effectiveness, prescription and adherence. We focus primarily on the monoclonal antibody class of PCSK9 inhibitors in this review while also touching on other types of therapeutics that are under development.

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PCSK9 Inhibitors in the Management of Cardiovascular Risk: A Practical Guidance

Abstract

Keywords

ASJC Scopus subject areas

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