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PCBs: Structure-function relationships and mechanism of action
S. Safe
, S. Bandiera, T. Sawyer
Academic Institute
Houston Methodist
Research output
:
Contribution to journal
›
Article
›
peer-review
287
Scopus citations
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Keyphrases
Mechanism of Action
100%
Polychlorinated Biphenyls
100%
Structure Function
100%
Coplanar Polychlorinated Biphenyls
100%
Aryl Hydrocarbon Hydroxylases
71%
Ortho
71%
Receptor-interacting Protein Kinase 1 (RIPK1)
57%
Cytochrome
42%
2,3,7,8-tetrachlorodibenzo-p-dioxin
42%
Tetrachlorobiphenyl
42%
TETRA
42%
C57BL
28%
Inducer
28%
Binding Affinity
28%
EC50
28%
Drug-metabolizing Enzymes
28%
Penta
28%
Aroclor 1254
28%
Hydroxylase
14%
High Dose
14%
Coplanar
14%
Hydrophobicity
14%
IC50 Value
14%
Regression Analysis
14%
Mouse Strain
14%
Competitive Binding
14%
Correlation Coefficient
14%
Receptor Binding
14%
Benzo(a)pyrene
14%
3-methylcholanthrene
14%
Ligand Binding
14%
Receptor-mediated
14%
Differential Effects
14%
Electronegativity
14%
Hydrogen Bonds (H-bonds)
14%
Halogenated Aromatic Hydrocarbons
14%
Ah Receptor
14%
Hepatoblastoma
14%
Ligand-receptor Interaction
14%
Chloro
14%
Structural Requirements
14%
Mixed Function Oxidases
14%
N-demethylase
14%
ED50
14%
Thymic Atrophy
14%
Demethylase
14%
PCB126
14%
H4IIE
14%
ECell
14%
Quantitative Structure-activity Relationship
14%
Cytosolic Receptors
14%
Halogenated Aromatics
14%
Polychlorinated Biphenyl Congeners
14%
Relative Toxicity
14%
Meta-position
14%
Halogenated Hydrocarbons
14%
Biological Potency
14%
Binding Avidity
14%
Biphenyl-3
14%
Halogenated PAHs
14%
Substitute Characteristics
14%
Pharmacology, Toxicology and Pharmaceutical Science
Polychlorinated Biphenyl
100%
Unspecific Monooxygenase
46%
2,3,7,8-Tetrachlorodibenzodioxin
38%
Receptor
30%
Receptor Protein
30%
Cytochrome
23%
2,3',4',5 Tetrachlorobiphenyl
23%
Carbon Tetrachloride
23%
DBA 2 Mouse
23%
EC50
23%
Aroclor 1254
15%
Drug Metabolizing Enzyme
15%
Hexachlorobiphenyl
15%
Aminophenazone
15%
C57BL 6 Mouse
7%
Liver Cell Carcinoma
7%
Aromatic Hydrocarbon Receptor
7%
Methylcholanthrene
7%
Aromatic Hydrocarbon
7%
Polycyclic Aromatic Hydrocarbon
7%
N Demethylase
7%
Mixed Function Oxidase
7%
Thymus Atrophy
7%
Mouse Strain
7%
Electronegativity
7%
Hydrophobicity
7%
Quantitative Structure Activity Relation
7%
Cytosol Receptor
7%
Halogenated Hydrocarbon
7%
Chemistry
Polychlorobiphenyl
100%
2,3,7,8-Tetrachlorodibenzodioxin
30%
Cytochrome
23%
EC50
23%
Kd
15%
Metabolic
15%
Hexachlorobiphenyl
15%
Aroclor 1254
15%
Aminophenazone
15%
Electronegativity
7%
Polycyclic Aromatic Hydrocarbon
7%
Arene
7%
Halogenated Hydrocarbon
7%
Ligand Binding
7%
Hydrophobicity
7%
Benzo[a]pyrene
7%
Mixed Function Oxidase
7%
Hydrogen Bonding
7%
2,3,4,5-tetrachlorobiphenyl
7%
3-Methylcholanthrene
7%
Tetrachlorobiphenyl
7%
ED50
7%
QSAR Study
7%
2,3,4,4',5-Pentachlorobiphenyl
7%
3,4,4',5-Tetrachlorobiphenyl
7%