TY - JOUR
T1 - PCBs and PBBs
T2 - Biologic and toxic effects on C57BL/6J and DBA/2J inbred mice
AU - Robertson, Larry W.
AU - Parkinson, Andrew
AU - Bandiera, Stelvio
AU - Lambert, Iain
AU - Merrill, Jill
AU - Safe, Stephen H.
N1 - Funding Information:
The financial assistance of the National Institutes of Health (1 R01 ES02798-01), the Natural Sciences and Engineering Research Council of Canada, and the Texas Agricultural Experiment Station (6766) are gratefully acknowledged.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1984/6
Y1 - 1984/6
N2 - Treatment of genetically inbred "responsive" C57BL/6J and "non-responsive" DBA/2J mice with Aroclor 1254 or fireMaster BP-6 resulted in the induction of hepatic microsomal benzo[a]pyrene hydroxylase only in the former mouse strain and aminopyrine N-demethylase in both strains of mice. In contrast, 3,3′,4,4′,5-pentachlorobiphenyl and 3,3′,4,4′-tetrabromobiphenyl, induced benzo[a]pyrene hydroxylase in both C57BL/6J and DBA/2J but did not enhance aminopyrine N-demethylase in either strain of mouse. Boo these coplanar halogenated biphenyls also caused thymic atrophy in the responsive and non-responsive mice and their effects resembled those of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Treatment of the inbred mice with several mono-ortho substituted analogs of the coplanar halogenated biphenyls, including 2,3,3′,4,4′-pentachloro-, 2,3′,4,4′,5-pentabromo, 2,3,3′,4,4′,5-hexachloro- and 3′,4′-dibromo-2,3,4,5-tetrachlorobiphenyl, gave hepatic enzyme-induction results similar to those observed for the commercial halogenated biphenyls. At dose levels of 1500 μmol/kg, most of these compounds caused thymic atrophy in C57BL/6J mice but not in DBA/2J mice. The structure-activity correlations in the mice complement similar studies with the halogenated biphenyls in rats and support the proposed receptor-mediated mechanism for the toxic halogenated aromatics.
AB - Treatment of genetically inbred "responsive" C57BL/6J and "non-responsive" DBA/2J mice with Aroclor 1254 or fireMaster BP-6 resulted in the induction of hepatic microsomal benzo[a]pyrene hydroxylase only in the former mouse strain and aminopyrine N-demethylase in both strains of mice. In contrast, 3,3′,4,4′,5-pentachlorobiphenyl and 3,3′,4,4′-tetrabromobiphenyl, induced benzo[a]pyrene hydroxylase in both C57BL/6J and DBA/2J but did not enhance aminopyrine N-demethylase in either strain of mouse. Boo these coplanar halogenated biphenyls also caused thymic atrophy in the responsive and non-responsive mice and their effects resembled those of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Treatment of the inbred mice with several mono-ortho substituted analogs of the coplanar halogenated biphenyls, including 2,3,3′,4,4′-pentachloro-, 2,3′,4,4′,5-pentabromo, 2,3,3′,4,4′,5-hexachloro- and 3′,4′-dibromo-2,3,4,5-tetrachlorobiphenyl, gave hepatic enzyme-induction results similar to those observed for the commercial halogenated biphenyls. At dose levels of 1500 μmol/kg, most of these compounds caused thymic atrophy in C57BL/6J mice but not in DBA/2J mice. The structure-activity correlations in the mice complement similar studies with the halogenated biphenyls in rats and support the proposed receptor-mediated mechanism for the toxic halogenated aromatics.
KW - Biologic and toxic effects
KW - Inbred mice
KW - Polychlorinated biphenyls
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U2 - 10.1016/0300-483X(84)90101-X
DO - 10.1016/0300-483X(84)90101-X
M3 - Article
C2 - 6330936
AN - SCOPUS:0021287963
SN - 0300-483X
VL - 31
SP - 191
EP - 206
JO - Toxicology
JF - Toxicology
IS - 3-4
ER -