PAX-2 in the diagnosis of primary renal tumors: Immunohistochemical comparison with renal cell carcinoma marker antigen and Kidney-Specific cadherin

Ayhan Ozcan, Jim Zhai, Candice Hamilton, Steven Shen, Jae Ro, Bhuvaneswan Knshnan, Luan Truong

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors. PAX-2 was successfully detected in routine tissue specimens. Although PAX-2 seems to be more sensitive than RCCM and KSC, there is significant staining overlap in relation to histologic subtypes, justifying the use of all 3 markers, which helps detect the vast majority of renal neoplasms. PAX-2 seems to have a significant role in renal neogenesis and may represent a novel therapeutic target.

Original languageEnglish (US)
Pages (from-to)393-404
Number of pages12
JournalAmerican Journal of Clinical Pathology
Volume131
Issue number3
DOIs
StatePublished - Mar 2009

Keywords

  • Immunohistochemistry
  • Kidney-specific cadherin; Renal cell carcinoma marker antigen
  • Nephrogenesis
  • PAX-2
  • RCCM
  • Renal neoplasm
  • Transcription factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'PAX-2 in the diagnosis of primary renal tumors: Immunohistochemical comparison with renal cell carcinoma marker antigen and Kidney-Specific cadherin'. Together they form a unique fingerprint.

Cite this