TY - JOUR
T1 - Patterns of spinal sensory-motor connectivity prescribed by a dorsoventral positional template
AU - Sürmeli, Gülen
AU - Akay, Turgay
AU - Ippolito, Gregory C.
AU - Tucker, Philip W.
AU - Jessell, Thomas M.
N1 - Funding Information:
We thank George Romanes for enlightening discussions on motor neuron groupings, Jeremy Dasen for insight into FoxP function, Joriene De Noiij for help with dorsal root fills, Gert Holstege for motor pool maps, Julia Kaltschmidt for contributions to the design of sensory-motor specificity assays, Tim Machado for statistical analysis of neuronal distributions, Richard Nichols and Trevor Drew for insight into limb biomechanics, John Kelly for detective work, Kendall Doerr for a sense of place, and Ira Schieren for assistance with figures and graphics. Kaity Miao, Monica Mendelsohn, June Harriss, and Deborah Surman helped in mouse genotyping and husbandry. Silvia Arber, Richard Axel, Jeremy Dasen, Joriene de Nooij, Jennifer Morgan, Chris Henderson, John Kelly, George Mentis, Richard Nichols, Sebastian Poliak, and George Romanes provided helpful comments on the manuscript. G.S. was supported by the Gatsby Charitable Foundation, and P.W.T. by NIH grant R01-CA31534 and the Marie Betzer Morrow endowment. T.M.J. is an Investigator of the Howard Hughes Medical Institute and was supported by NIH grants R01-NS033245 and P01-NS055923, ProjectALS/P 2 ALS, The Wellcome Trust, NYSTEM, and The Harold and Leila Mathers Foundation.
PY - 2011/10/28
Y1 - 2011/10/28
N2 - Sensory-motor circuits in the spinal cord are constructed with a fine specificity that coordinates motor behavior, but the mechanisms that direct sensory connections with their motor neuron partners remain unclear. The dorsoventral settling position of motor pools in the spinal cord is known to match the distal-to-proximal position of their muscle targets in the limb, but the significance of invariant motor neuron positioning is unknown. An analysis of sensory-motor connectivity patterns in FoxP1 mutant mice, where motor neuron position has been scrambled, shows that the final pattern of sensory-motor connections is initiated by the projection of sensory axons to discrete dorsoventral domains of the spinal cord without regard for motor neuron subtype or, indeed, the presence of motor neurons. By implication, the clustering and dorsoventral settling position of motor neuron pools serve as a determinant of the pattern of sensory input specificity and thus motor coordination. PaperClip:
AB - Sensory-motor circuits in the spinal cord are constructed with a fine specificity that coordinates motor behavior, but the mechanisms that direct sensory connections with their motor neuron partners remain unclear. The dorsoventral settling position of motor pools in the spinal cord is known to match the distal-to-proximal position of their muscle targets in the limb, but the significance of invariant motor neuron positioning is unknown. An analysis of sensory-motor connectivity patterns in FoxP1 mutant mice, where motor neuron position has been scrambled, shows that the final pattern of sensory-motor connections is initiated by the projection of sensory axons to discrete dorsoventral domains of the spinal cord without regard for motor neuron subtype or, indeed, the presence of motor neurons. By implication, the clustering and dorsoventral settling position of motor neuron pools serve as a determinant of the pattern of sensory input specificity and thus motor coordination. PaperClip:
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U2 - 10.1016/j.cell.2011.10.012
DO - 10.1016/j.cell.2011.10.012
M3 - Article
C2 - 22036571
AN - SCOPUS:80155148101
SN - 0092-8674
VL - 147
SP - 653
EP - 665
JO - Cell
JF - Cell
IS - 3
ER -