Patterned protein layers on solid substrates by thin stamp microcontact printing

C. D. James, R. C. Davis, L. Kam, H. G. Craighead, M. Isaacson, J. N. Turner, W. Shain

Research output: Contribution to journalArticlepeer-review

264 Scopus citations


Microcontact printing (μCP) is a new method of molecularly patterning surfaces on a micrometer scale. In this paper, we present the extension of microcontact printing to producing patterned layers of proteins on solid substrates. μCP avoids the use of strong acids and bases necessary in photolithographic patterning, allowing its use for patterning of proteins and other biological layers. We also describe the methods of thin stamp microcontact printing that allow printing of isolated features previously unattainable by microcontact printing. A solution of polylysine in borate-buffered saline was printed onto a glass coverslip, yielding micrometer scale features over an area of 4 cm2.

Original languageEnglish (US)
Pages (from-to)741-744
Number of pages4
Issue number4
StatePublished - Feb 17 1998

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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