TY - JOUR
T1 - Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome
AU - Yanez-Perez, Roraima
AU - Garcia-Cabello, Eloy
AU - Habich, Annegret
AU - Cedres, Nira
AU - Diaz-Galvan, Patricia
AU - Abdelnour, Carla
AU - Toledo, Jon B
AU - Barroso, José
AU - Ferreira, Daniel
N1 - © 2025. The Author(s).
PY - 2025/1/6
Y1 - 2025/1/6
N2 - Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive connectome of DLB patients, healthy controls (HC), and Alzheimer's disease patients (AD). We obtained data from the National Alzheimer's Coordinating Center. We built cognitive connectomes for DLB (n = 104), HC (n = 3703), and AD (n = 1985) using correlations among 24 cognitive measures mapping multiple cognitive domains. Connectomes were compared using global and nodal graph measures of centrality, integration, and segregation. For global measures, DLB showed a higher global efficiency (integration) and lower transitivity (segregation) than HC and AD. For nodal measures, DLB showed higher global efficiency in most measures, higher participation (centrality) in free-recall memory, processing speed/attention, and executive measures, and lower local efficiency (segregation) than HC. Compared with AD, DLB showed lower nodal strength and local efficiency, especially in memory consolidation. The cognitive connectome of DLB shows a loss of segregation, leading to a loss of cognitive specialization. This study provides the data to advance the understanding of cognitive impairment and clinical phenotype in DLB, with implications for differential diagnosis.
AB - Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive connectome of DLB patients, healthy controls (HC), and Alzheimer's disease patients (AD). We obtained data from the National Alzheimer's Coordinating Center. We built cognitive connectomes for DLB (n = 104), HC (n = 3703), and AD (n = 1985) using correlations among 24 cognitive measures mapping multiple cognitive domains. Connectomes were compared using global and nodal graph measures of centrality, integration, and segregation. For global measures, DLB showed a higher global efficiency (integration) and lower transitivity (segregation) than HC and AD. For nodal measures, DLB showed higher global efficiency in most measures, higher participation (centrality) in free-recall memory, processing speed/attention, and executive measures, and lower local efficiency (segregation) than HC. Compared with AD, DLB showed lower nodal strength and local efficiency, especially in memory consolidation. The cognitive connectome of DLB shows a loss of segregation, leading to a loss of cognitive specialization. This study provides the data to advance the understanding of cognitive impairment and clinical phenotype in DLB, with implications for differential diagnosis.
KW - Humans
KW - Lewy Body Disease/physiopathology
KW - Connectome
KW - Female
KW - Male
KW - Aged
KW - Alzheimer Disease/physiopathology
KW - Cognition/physiology
KW - Aged, 80 and over
KW - Magnetic Resonance Imaging
KW - Cognitive Dysfunction/physiopathology
KW - Brain/diagnostic imaging
KW - Neuropsychological Tests
U2 - 10.1038/s41598-024-84946-4
DO - 10.1038/s41598-024-84946-4
M3 - Article
C2 - 39762366
SN - 2045-2322
VL - 15
SP - 940
JO - Scientific Reports
JF - Scientific Reports
IS - 1
ER -