Patient-specific modelling of blood flow dynamics in intra-cranial aneurysms: an example of image-based personalised medicine

Research output: Contribution to journalArticle

Abstract

The visualisation of blood flow dynamics in intracranial aneurysm using computational fluid dynamics is an example of personalised medicine based on biomedical image analysis. A small percentage of these aneurysms rupture. Blood flow dynamics is thought to play an important role in the rupture process by exerting Wall Shear Stresses (WSS) on the endothelial cells. In this study, the effects of instabilities in the velocity waveform in the parent artery of an aneurysm of the Internal Carotid Artery (ICA) and variations of the computational mesh are investigated with respect to WSS at the aneurysm wall.

Original languageEnglish (US)
Pages (from-to)150-158
Number of pages9
JournalInternational Journal of Functional Informatics and Personalised Medicine
Volume2
Issue number2
DOIs
StatePublished - 2009

Keywords

  • cerebral blood flow
  • computational fluid dynamics
  • hemodynamics
  • intracranial aneurysms
  • wall shear stresses

ASJC Scopus subject areas

  • Clinical Neurology

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