Pathophysiology of vein graft failure: A review

Mark G. Davies; Per Otto Hagen

doi:10.1016/S1078-5884(05)80218-7

Pathophysiology of vein graft failure: A review

Mark G. Davies, Per Otto Hagen

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

278 Scopus citations

Abstract

Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.

Original language	English (US)
Pages (from-to)	7-18
Number of pages	12
Journal	European Journal of Vascular and Endovascular Surgery
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S1078-5884(05)80218-7
State	Published - Jan 1995

Keywords

Atherosclerosis
Failure
Intimal hyperplasia
Smooth muscle cell endothelium
Vein
Vein graft

ASJC Scopus subject areas

Surgery
Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/S1078-5884(05)80218-7

Cite this

@article{3f0e21ab70e047acadb0a22931b9f4dc,

title = "Pathophysiology of vein graft failure: A review",

abstract = "Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.",

keywords = "Atherosclerosis, Failure, Intimal hyperplasia, Smooth muscle cell endothelium, Vein, Vein graft",

author = "Davies, {Mark G.} and Hagen, {Per Otto}",

note = "Funding Information: The authors would like to express their gratitude to Dr K.G.M. Brockbank and Ms L. Barber for their assistance and advice in the preparation Of this manuscript. Grant Support: U.S. Public Health Service HL 15448. American Heart Association (NC Affiliate) NC 92-GB-31 Mark G. Davies is supported by a N.I.H. Fogarty International Research Fellowship (TW 04810) and holds a Royal College of Surgeons in Ireland Surgical Travelling Fellowship and a Trinity College Dublin Postgraduate Scholarship.",

year = "1995",

month = jan,

doi = "10.1016/S1078-5884(05)80218-7",

language = "English (US)",

volume = "9",

pages = "7--18",

journal = "European Journal of Vascular and Endovascular Surgery",

issn = "1078-5884",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Pathophysiology of vein graft failure

T2 - A review

AU - Davies, Mark G.

AU - Hagen, Per Otto

N1 - Funding Information: The authors would like to express their gratitude to Dr K.G.M. Brockbank and Ms L. Barber for their assistance and advice in the preparation Of this manuscript. Grant Support: U.S. Public Health Service HL 15448. American Heart Association (NC Affiliate) NC 92-GB-31 Mark G. Davies is supported by a N.I.H. Fogarty International Research Fellowship (TW 04810) and holds a Royal College of Surgeons in Ireland Surgical Travelling Fellowship and a Trinity College Dublin Postgraduate Scholarship.

PY - 1995/1

Y1 - 1995/1

N2 - Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.

AB - Vein bypass grafting is an integral component of cardiovascular surgical practice for both arterial and venous diseases. However, many of these grafts will eventually fail due to either intrinsic or extrinsic causes. This review examines the current understanding and knowledge of venous histology, vein graft pathology and the associated endothelial and smooth muscle cell physiology and pharmacology. In addition, the status of research on the therapeutic control of vein graft intimal hyperplasia and accelerated atherosclerosis is assessed.

KW - Atherosclerosis

KW - Failure

KW - Intimal hyperplasia

KW - Smooth muscle cell endothelium

KW - Vein

KW - Vein graft

UR - http://www.scopus.com/inward/record.url?scp=0028966645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028966645&partnerID=8YFLogxK

U2 - 10.1016/S1078-5884(05)80218-7

DO - 10.1016/S1078-5884(05)80218-7

M3 - Review article

C2 - 7664016

AN - SCOPUS:0028966645

SN - 1078-5884

VL - 9

SP - 7

EP - 18

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 1

ER -

Pathophysiology of vein graft failure: A review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this