TY - JOUR
T1 - Pathophysiology of atherosclerotic vascular disease
AU - Cooke, John P.
AU - Bhatnagar, Ritu
PY - 1997
Y1 - 1997
N2 - Endothelium-derived relaxing factor is a potent endogenous vasodilator. This substance is now known to be nitric oxide, which is derived from the metabolism of L-arginine. This potent vasodilator also inhibits interactions of circulating blood elements with the vessel wall. Platelet adherence and aggregation, as well as monocyte adherence and infiltration, are regulated by this paracrine factor. By virtue of these characteristics, nitric oxide inhibits atherogenesis.
AB - Endothelium-derived relaxing factor is a potent endogenous vasodilator. This substance is now known to be nitric oxide, which is derived from the metabolism of L-arginine. This potent vasodilator also inhibits interactions of circulating blood elements with the vessel wall. Platelet adherence and aggregation, as well as monocyte adherence and infiltration, are regulated by this paracrine factor. By virtue of these characteristics, nitric oxide inhibits atherogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0345527518&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345527518&partnerID=8YFLogxK
U2 - 10.2165/00115677-199700021-00003
DO - 10.2165/00115677-199700021-00003
M3 - Article
AN - SCOPUS:0345527518
VL - 2
SP - 1
EP - 8
JO - Disease Management and Health Outcomes
JF - Disease Management and Health Outcomes
SN - 1173-8790
IS - SUPPL. 1
ER -