Pathophysiology of atherosclerotic vascular disease

John P. Cooke; Ritu Bhatnagar

doi:10.2165/00115677-199700021-00003

Pathophysiology of atherosclerotic vascular disease

John P. Cooke, Ritu Bhatnagar

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Endothelium-derived relaxing factor is a potent endogenous vasodilator. This substance is now known to be nitric oxide, which is derived from the metabolism of L-arginine. This potent vasodilator also inhibits interactions of circulating blood elements with the vessel wall. Platelet adherence and aggregation, as well as monocyte adherence and infiltration, are regulated by this paracrine factor. By virtue of these characteristics, nitric oxide inhibits atherogenesis.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Disease Management and Health Outcomes
Volume	2
Issue number	SUPPL. 1
DOIs	https://doi.org/10.2165/00115677-199700021-00003
State	Published - 1997

ASJC Scopus subject areas

Leadership and Management
Nursing(all)
Health Policy

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