TY - JOUR
T1 - Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration
AU - Lopez, P. F.
AU - Grossniklaus, H. E.
AU - Lambert, H. M.
AU - Aaberg, T. M.
AU - Capone, A.
AU - Sternberg, P.
AU - L'Hernault, N.
N1 - Funding Information:
From the Department of Ophthalmology, Emory University, Atlanta, Georgia (Drs. Lopez, Crossniklaus, Lambert, Aaberg, Capone, and Sternberg and Ms. L'Hernault); and 1. F. Montgomery Ophthalmic Pathology Laboratory (Drs. Grossniklaus and Ms. L'Hernault). This study was supported in part by an unrestricted departmental grant from Research to Prevent Blindness, Inc., New York, New York, and departmental core grant EY06360. Dr. Lopez was a 1990-1991 Heed Ophthalmic Fellow.
PY - 1991
Y1 - 1991
N2 - The histopathologic features of ten consecutive surgically excised subfoveal neovascular membranes from patients with age-related macular degeneration were examined. Ultrastructural features included the following in decreasing order of frequency: endothelium-lined vascular channels, new collagen, fibrocytes, retinal pigment epithelium, erythrocytes, and myofibroblasts. Chronic inflammatory cells were frequently evident and included macrophages, lymphocytes, and plasma cells. Basal laminar deposit or diffuse drusen were observed in six of the membranes. Photoreceptors and Bruch's membrane were each observed in three of the specimens, but were not associated with decreased postoperative visual acuity. Fibrin was observed in eight membranes, either within the stroma of the membrane or in association with subretinal hemorrhage.
AB - The histopathologic features of ten consecutive surgically excised subfoveal neovascular membranes from patients with age-related macular degeneration were examined. Ultrastructural features included the following in decreasing order of frequency: endothelium-lined vascular channels, new collagen, fibrocytes, retinal pigment epithelium, erythrocytes, and myofibroblasts. Chronic inflammatory cells were frequently evident and included macrophages, lymphocytes, and plasma cells. Basal laminar deposit or diffuse drusen were observed in six of the membranes. Photoreceptors and Bruch's membrane were each observed in three of the specimens, but were not associated with decreased postoperative visual acuity. Fibrin was observed in eight membranes, either within the stroma of the membrane or in association with subretinal hemorrhage.
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U2 - 10.1016/S0002-9394(14)77270-8
DO - 10.1016/S0002-9394(14)77270-8
M3 - Article
C2 - 1957899
AN - SCOPUS:0026048702
SN - 0002-9394
VL - 112
SP - 647
EP - 656
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -