Pathobiology of intimal hyperplasia

M. G. Davies, P. ‐O Hagen

Research output: Contribution to journalReview articlepeer-review

375 Scopus citations


In the current vascular interventional environment, high restenosis rates have increased awareness of the significance of intimal hyperplasia, a chronic structural lesion that develops after vessel wall injury, and which can lead to luminal stenosis and occlusion. Intimal hyperplasia may be defined as the abnormal migration and proliferation of vascular smooth muscle cells with associated deposition of extracellular connective tissue matrix. The pathology of intimal hyperplasia is reviewed with particular attention to its physiology, pharmacology, cell biology and molecular biology.

Original languageEnglish (US)
Pages (from-to)1254-1269
Number of pages16
JournalBritish Journal of Surgery
Issue number9
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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