Particulate systems for targeting of macrophages: Basic and therapeutic concepts

S. M. Moghimi, L. Parhamifar, D. Ahmadvand, P. P. Wibroe, T. L. Andresen, Z. S. Farhangrazi, A. C. Hunter

    Research output: Contribution to journalReview articlepeer-review

    67 Scopus citations

    Abstract

    Particulate systems in the form of liposomes, polymeric micelles, polymeric nano-and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physicochemical properties, which include hydrodynamic size, shape, composition and surface characteristics. Through such modifications together with understanding of macrophage cell biology, targeting may be aimed at a particular subset of macrophages. Advances in basic and therapeutic concepts of particulate targeting of macrophages and related nanotechnology approaches for immune cell modifications are discussed.

    Original languageEnglish (US)
    Pages (from-to)509-528
    Number of pages20
    JournalJournal of Innate Immunity
    Volume4
    Issue number5-6
    DOIs
    StatePublished - Aug 2012

    Keywords

    • Drug delivery
    • Macrophage diseases
    • Nanomedicine
    • Nanoparticles
    • Phagocytosis

    ASJC Scopus subject areas

    • Immunology and Allergy

    Fingerprint

    Dive into the research topics of 'Particulate systems for targeting of macrophages: Basic and therapeutic concepts'. Together they form a unique fingerprint.

    Cite this