Particulate nanomedicine in the footsteps of platelet homing

S. Moein Moghimi; Islam Hamad; A. Christy Hunter

doi:10.2217/17435889.2.3.381

Particulate nanomedicine in the footsteps of platelet homing

S. Moein Moghimi, Islam Hamad, A. Christy Hunter

Research output: Contribution to journal › Article › peer-review

Abstract

An exciting nanoparticulate system is described as being capable of targeting resident clotted plasma proteins located in tumor vasculature, in which the particles amplify their own homing. The system appears to overcome the poor efficiency usually encountered in targeting components of the vascular system with nanoparticulate entities. This simultaneous homing and amplification process mimics platelet homing and accumulation at sites of vascular injury. These results are a promising beginning for the design of different self-amplifying homing-enabled particulate nanomedicines for the simultaneous monitoring and treatment of experimental malignancies as well as other areas involving pathological clotting activity.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Nanomedicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.2217/17435889.2.3.381
State	Published - Jun 2007

Keywords

Blood clot
Cancer
Iron oxide nanocrystal
Liposome
Peptide
Tumor targeting

ASJC Scopus subject areas

General Materials Science
Bioengineering
Biomedical Engineering
Medicine (miscellaneous)
Development

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10.2217/17435889.2.3.381

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title = "Particulate nanomedicine in the footsteps of platelet homing",

abstract = "An exciting nanoparticulate system is described as being capable of targeting resident clotted plasma proteins located in tumor vasculature, in which the particles amplify their own homing. The system appears to overcome the poor efficiency usually encountered in targeting components of the vascular system with nanoparticulate entities. This simultaneous homing and amplification process mimics platelet homing and accumulation at sites of vascular injury. These results are a promising beginning for the design of different self-amplifying homing-enabled particulate nanomedicines for the simultaneous monitoring and treatment of experimental malignancies as well as other areas involving pathological clotting activity.",

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AB - An exciting nanoparticulate system is described as being capable of targeting resident clotted plasma proteins located in tumor vasculature, in which the particles amplify their own homing. The system appears to overcome the poor efficiency usually encountered in targeting components of the vascular system with nanoparticulate entities. This simultaneous homing and amplification process mimics platelet homing and accumulation at sites of vascular injury. These results are a promising beginning for the design of different self-amplifying homing-enabled particulate nanomedicines for the simultaneous monitoring and treatment of experimental malignancies as well as other areas involving pathological clotting activity.

KW - Blood clot

KW - Cancer

KW - Iron oxide nanocrystal

KW - Liposome

KW - Peptide

KW - Tumor targeting

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Particulate nanomedicine in the footsteps of platelet homing

Abstract

Keywords

ASJC Scopus subject areas

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