Particulate nanomedicine in the footsteps of platelet homing

Seyed Moghimi, Islam Hamad, A. Christy Hunter

Research output: Contribution to journalArticle

Abstract

An exciting nanoparticulate system is described as being capable of targeting resident clotted plasma proteins located in tumor vasculature, in which the particles amplify their own homing. The system appears to overcome the poor efficiency usually encountered in targeting components of the vascular system with nanoparticulate entities. This simultaneous homing and amplification process mimics platelet homing and accumulation at sites of vascular injury. These results are a promising beginning for the design of different self-amplifying homing-enabled particulate nanomedicines for the simultaneous monitoring and treatment of experimental malignancies as well as other areas involving pathological clotting activity.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalNanomedicine
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2007

Keywords

  • Blood clot
  • Cancer
  • Iron oxide nanocrystal
  • Liposome
  • Peptide
  • Tumor targeting

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

Fingerprint Dive into the research topics of 'Particulate nanomedicine in the footsteps of platelet homing'. Together they form a unique fingerprint.

Cite this