Particle size distribution of iron nanomaterials in biological medium by SR-SAXS method

Yun Wang, Long Jing, Weiyue Feng, Bing Wang, Huajian Wang, Motao Zhu, Meng Wang, Hong Ouyang, Yuliang Zhao, Zhifang Chai, Zhonghua Wu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A better understanding of biological effects of nanomaterials in organisms requests knowledge of the physicochemical properties of nanomaterials in biological systems. Affected by high concentration salts and proteins in biological medium, nanoparticles are much easy to agglomerate, hence the difficulties in characterizing size distribution of the nanomaterials in biological medium. In this work, synchrotron radiation small angle X-ray scattering (SR-SAXS) was used to determine size distributions of Fe, Fe2O3 and Fe3O4 nanoparticles of various concentrations in PBS and DMEM culture medium. The results show that size distributions of the nanomaterials could perfectly analyzed by SR-SAXS. The SR-SAXS data were not affected by the particle content and types of the dispersion medium. It is concluded that SR-SAXS can be used for size measurement of nanomaterials in unstable dispersion systems.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalHe Jishu/Nuclear Techniques
Issue number1
StatePublished - Jan 2009


  • Dispersion system
  • Nanoparticles
  • Particle size distributions
  • Small Angle X-ray Scattering

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiation
  • Nuclear and High Energy Physics


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