Particle platforms for cancer immunotherapy

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Elevated understanding and respect for the relevance of the immune system in cancer development and therapy has led to increased development of immunotherapeutic regimens that target existing cancer cells and provide long-term immune surveillance and protection from cancer recurrence. This review discusses using particles as immune adjuvants to create vaccines and to augment the anticancer effects of conventional chemotherapeutics. Several particle prototypes are presented, including liposomes, polymer nanoparticles, and porous silicon microparticles, the latter existing as either single- or multiparticle platforms. The benefits of using particles include immune-cell targeting, codelivery of antigens and immunomodulatory agents, and sustained release of the therapeutic payload. Nanotherapeutic-based activation of the immune system is dependent on both intrinsic particle characteristics and on the immunomodulatory cargo, which may include danger signals known as pathogen-associated molecular patterns and cytokines for effector-cell activation.

Original languageEnglish (US)
Pages (from-to)1683-1696
Number of pages14
JournalInternational Journal of Nanomedicine
Volume8
DOIs
StatePublished - Apr 26 2013

Keywords

  • Adjuvant
  • Cancer
  • Dendritic cell
  • Immunotherapy
  • Particle
  • Vaccine

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery

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