Uchastie endogennoǐ opioidnoǐ sistemy v formirovanii otvetnoǐ reaktsii organizma na stressovye vozdeǐstviia.

Translated title of the contribution: Participation of the endogenous opioid system in the formation of the body's response to stress

Eugene V. Golanov, A. A. Fufacheva, G. M. Cherkovich

Research output: Contribution to journalArticle

Abstract

Autonomic responses to acute stressors in unanesthetized, chair-restrained baboons and macacas include elevations in heart rate, blood pressure and respiratory rate. Naloxone, in a dose of 1.0 mg/kg intravenously, as well as morphine (1.0 mg/kg) suppresses autonomic alterations produced by the introduction of conditioned and unconditioned stimuli. When given in a dose of 0.1 mg/kg, naloxone, on the contrary, facilitates autonomic responses. The autonomic changes induced by electrical stimulation of the medial hypothalamus and nucleus tractus solitarius are influenced by naloxone--in both doses--and by morphine in the opposite manner. These data, as well as those derived from experiments on the effects of micro-injections of naloxone and morphine into the medial hypothalamus and nucleus tractus solitarius suggest that the endogenous opioid system is necessary to display complete autonomic response pattern in monkeys. A hypothesis is proposed to the effect that endogenous opioid system is important for establishing a precise correspondence between the body's potentialities and behavior, and environmental demands.

Translated title of the contributionParticipation of the endogenous opioid system in the formation of the body's response to stress
Original languageRussian
Pages (from-to)67-71
Number of pages5
JournalKardiologiia
Volume26
Issue number5
StatePublished - May 1 1986

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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