Partially polymerized liposomes: Stable against leakage yet capable of instantaneous release for remote controlled drug delivery

Guoting Qin, Zheng Li, Rongmin Xia, Feng Li, Brian E. O'Neill, Jessica T. Goodwin, Htet A. Khant, Wah Chiu, King C. Li

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A critical issue for current liposomal carriers in clinical applications is their leakage of the encapsulated drugs that are cytotoxic to non-target tissues. We have developed partially polymerized liposomes composed of polydiacetylene lipids and saturated lipids. Cross-linking of the diacetylene lipids prevents the drug leakage even at 40 °C for days. These inactivated drug carriers are non-cytotoxic. Significantly, more than 70% of the encapsulated drug can be instantaneously released by a laser that matches the plasmon resonance of the tethered gold nanoparticles on the liposomes, and the therapeutic effect was observed in cancer cells. The remote activation feature of this novel drug delivery system allows for precise temporal and spatial control of drug release.

Original languageEnglish (US)
Article number155605
JournalNanotechnology
Volume22
Issue number15
DOIs
StatePublished - Apr 15 2011

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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