Parkinson's disease: A role for the immune system

Research output: Contribution to journalReview article

Dwight C. German, Todd N. Eagar, Patricia K. Sonsalla

Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to play a role in the neurodegenerative process, and may contribute to disease progression. Here we review the neuropathology of PD with attention focused on the involvement of the innate immune cells (microglia) and the adaptive immune cells (T lymphocytes). In addition, we discuss animal models of the disease with emphasis on a progressive rat model which allows a detailed analysis of how the immune system contributes to neurodegeneration both during early and late stages of degeneration. Finally, for the early detection and treatment of PD, we discuss immunotherapy approaches.

Original languageEnglish (US)
Pages (from-to)340-349
Number of pages10
JournalCurrent Molecular Pharmacology
Volume5
Issue number3
DOIs
StatePublished - Dec 1 2012

Altmetrics

Cite this

Standard

Parkinson's disease : A role for the immune system. / German, Dwight C.; Eagar, Todd N.; Sonsalla, Patricia K.

In: Current Molecular Pharmacology, Vol. 5, No. 3, 01.12.2012, p. 340-349.

Research output: Contribution to journalReview article

Harvard

German, DC, Eagar, TN & Sonsalla, PK 2012, 'Parkinson's disease: A role for the immune system' Current Molecular Pharmacology, vol. 5, no. 3, pp. 340-349. https://doi.org/10.2174/1874467211205030003

APA

German, D. C., Eagar, T. N., & Sonsalla, P. K. (2012). Parkinson's disease: A role for the immune system. Current Molecular Pharmacology, 5(3), 340-349. https://doi.org/10.2174/1874467211205030003

Vancouver

German DC, Eagar TN, Sonsalla PK. Parkinson's disease: A role for the immune system. Current Molecular Pharmacology. 2012 Dec 1;5(3):340-349. https://doi.org/10.2174/1874467211205030003

Author

German, Dwight C. ; Eagar, Todd N. ; Sonsalla, Patricia K. / Parkinson's disease : A role for the immune system. In: Current Molecular Pharmacology. 2012 ; Vol. 5, No. 3. pp. 340-349.

BibTeX

@article{107549de27ed4ed78be9effeaa2782db,
title = "Parkinson's disease: A role for the immune system",
abstract = "Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to play a role in the neurodegenerative process, and may contribute to disease progression. Here we review the neuropathology of PD with attention focused on the involvement of the innate immune cells (microglia) and the adaptive immune cells (T lymphocytes). In addition, we discuss animal models of the disease with emphasis on a progressive rat model which allows a detailed analysis of how the immune system contributes to neurodegeneration both during early and late stages of degeneration. Finally, for the early detection and treatment of PD, we discuss immunotherapy approaches.",
keywords = "Dopamine, Glia, Inflammation, MPTP, Neurodegeneration, Peptoids, T cells",
author = "German, {Dwight C.} and Eagar, {Todd N.} and Sonsalla, {Patricia K.}",
year = "2012",
month = "12",
day = "1",
doi = "10.2174/1874467211205030003",
language = "English (US)",
volume = "5",
pages = "340--349",
journal = "Current Molecular Pharmacology",
issn = "1874-4672",
publisher = "Bentham Science Publishers Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Parkinson's disease

T2 - Current Molecular Pharmacology

AU - German, Dwight C.

AU - Eagar, Todd N.

AU - Sonsalla, Patricia K.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to play a role in the neurodegenerative process, and may contribute to disease progression. Here we review the neuropathology of PD with attention focused on the involvement of the innate immune cells (microglia) and the adaptive immune cells (T lymphocytes). In addition, we discuss animal models of the disease with emphasis on a progressive rat model which allows a detailed analysis of how the immune system contributes to neurodegeneration both during early and late stages of degeneration. Finally, for the early detection and treatment of PD, we discuss immunotherapy approaches.

AB - Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with the loss of catecholaminergic neurons in several brain regions. The motor symptoms of the disease are related to degeneration of the midbrain dopaminergic neurons, which occurs some time after the disease has begun. Both the innate and adaptive immune systems appear to play a role in the neurodegenerative process, and may contribute to disease progression. Here we review the neuropathology of PD with attention focused on the involvement of the innate immune cells (microglia) and the adaptive immune cells (T lymphocytes). In addition, we discuss animal models of the disease with emphasis on a progressive rat model which allows a detailed analysis of how the immune system contributes to neurodegeneration both during early and late stages of degeneration. Finally, for the early detection and treatment of PD, we discuss immunotherapy approaches.

KW - Dopamine

KW - Glia

KW - Inflammation

KW - MPTP

KW - Neurodegeneration

KW - Peptoids

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=84874919774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874919774&partnerID=8YFLogxK

U2 - 10.2174/1874467211205030003

DO - 10.2174/1874467211205030003

M3 - Review article

VL - 5

SP - 340

EP - 349

JO - Current Molecular Pharmacology

JF - Current Molecular Pharmacology

SN - 1874-4672

IS - 3

ER -

ID: 16823571