TY - JOUR
T1 - Paratesticular clear cell carcinoma of müllerian origin—A case report
AU - Warmke, Laura
AU - Vining, David
AU - Ward, John
AU - Lin, Michelle
AU - Ro, Jae Y.
AU - Zhang, Miao
N1 - Publisher Copyright:
© 2020 The Authors
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/9
Y1 - 2020/9
N2 - Ovarian epithelial-type tumors of the testis and paratestis are very rare, comprising <0.1% of testicular tumors. Among ovarian epithelial-type tumors, clear cell carcinoma of Müllerian origin is the least common subtype with very few cases reported in the literature. Herein we report the histologic features, immunohistochemical characteristics and aggressive clinical course of a primary clear cell carcinoma of Müllerian origin involving the paratestis and testicular parenchyma, arising in a 68-year-old patient. We show that the immunophenotypic features of this rare tumor are similar to its ovarian counterpart, demonstrating positivity for PAX8, HNF-1β and p504s. The positivity for HNF-1β and p504s is especially helpful as PAX8 positivity is present in metastatic clear cell renal cell carcinoma, one of the main diagnostic pitfalls. We also review other published cases to evaluate prognosis and treatment. Given the aggressive nature of this tumor, knowledge of this rare entity with early recognition is essential.
AB - Ovarian epithelial-type tumors of the testis and paratestis are very rare, comprising <0.1% of testicular tumors. Among ovarian epithelial-type tumors, clear cell carcinoma of Müllerian origin is the least common subtype with very few cases reported in the literature. Herein we report the histologic features, immunohistochemical characteristics and aggressive clinical course of a primary clear cell carcinoma of Müllerian origin involving the paratestis and testicular parenchyma, arising in a 68-year-old patient. We show that the immunophenotypic features of this rare tumor are similar to its ovarian counterpart, demonstrating positivity for PAX8, HNF-1β and p504s. The positivity for HNF-1β and p504s is especially helpful as PAX8 positivity is present in metastatic clear cell renal cell carcinoma, one of the main diagnostic pitfalls. We also review other published cases to evaluate prognosis and treatment. Given the aggressive nature of this tumor, knowledge of this rare entity with early recognition is essential.
KW - Clear cell tumors
KW - Müllerian tumors
KW - Ovarian epithelial-type tumors of testis
KW - Paratesticular tumors
KW - Testicular tumors
UR - http://www.scopus.com/inward/record.url?scp=85090033960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090033960&partnerID=8YFLogxK
U2 - 10.1016/j.ehpc.2020.200401
DO - 10.1016/j.ehpc.2020.200401
M3 - Article
AN - SCOPUS:85090033960
VL - 21
JO - Human Pathology: Case Reports
JF - Human Pathology: Case Reports
SN - 2214-3300
M1 - 200401
ER -