Parasitic protozoa and interactions with the host intestinal microbiota

Stacey L. Burgess, Carol A. Gilchrist, Tucker C. Lynn, William A. Petri

Research output: Contribution to journalShort surveypeer-review

85 Scopus citations

Abstract

Parasitic protozoan infections represent a major health burden in the developing world and contribute significantly to morbidity and mortality. These infections are often associated with considerable variability in clinical presentation. An emerging body of work suggests that the intestinal microbiota may help to explain some of these differences in disease expression. The objective of this minireview is to synthesize recent progress in this rapidly advancing field. Studies of humans and animals and in vitro studies of the contribution of the intestinal microbiota to infectious disease are discussed. We hope to provide an understanding of the humanprotozoal pathogen-microbiome interaction and to speculate on how that might be leveraged for treatment.

Original languageEnglish (US)
Article numbere00101-17
JournalInfection and Immunity
Volume85
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • Host pathogen
  • Microbiota
  • Parasite
  • Protozoa

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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