Pancreatic adenocarcinoma tumor grade determination using contrast-enhanced magnetic resonance imaging

Thomas C. Lauenstein, Diego R. Martin, Juan M. Sarmiento, Bobby Kalb, Roger Moreira, John Carew, Khalil Salman, Volkan Adsay

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: To determine whether the degree of enhancement of pancreatic adenocarcinoma visualized on arterial phase gadolinium-enhanced magnetic resonance imaging (MRI) correlates with the histopathological tumor grade. Methods: Thirty-nine patients with pancreatic adenocarcinoma had MRI within 14 days before tumor resection. Gadolinium-chelate-enhanced (Gd) 3-dimensional gradient echo images were acquired including the arterial phase. Tumor imaging patterns on the arterial phase images were classified for low, moderate, or high degree of enhancement and compared against conventional histological grading. Results: Based on histological grading, there were 12 poorly differentiated, 2 poorly to moderately differentiated, 22 moderately differentiated, and 3 well-differentiated adenocarcinomas. There was agreement between the MRI arterial enhancement pattern and histological grading in 30 of 39 cases. The mean size of tumors grouped by enhancement pattern or grade was not significantly different between groups. Although minor discordance was found in 9 of the 39 cases, statistical analysis showed agreement between the degree of arterial enhancement on MRI and histological tumor differentiation; the Cohen's kappa value was 0.64 with a 95% confidence interval of 0.46-0.83. Conclusions: Pancreatic adenocarcinoma arterial phase enhancement correlates with the histological grade of differentiation.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
Issue number1
StatePublished - Jan 2010


  • Enhancement
  • MRI
  • Noninvasive evaluation
  • Pancreatic adenocarcinoma
  • Tumor histology

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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