Pallidotomy for generalized dystonia

William G. Ondo, Michael Desaloms, Joseph Jankovic, Robert G. Grossman

Research output: Contribution to journalArticlepeer-review

185 Scopus citations


We systematically evaluated the efficacy of both unilateral and bilateral stereotactic pallidotomy in eight patients with generalized dystonia. Six patients had a marked improvement in dystonic movements and motor function; the other two patients also benefited from the procedure but to a lesser extent. The severity of dystonia was assessed before and after surgery by the Burke-Marsden-Fahn Dystonia Scale (BMFDS), the Unified Dystonia Rating Scale (UDRS), and the Activity of Daily Living Scale (ADL). The BMFDS scores decreased by 59.0%, UDRS by 62.5%, and ADL by 47.8% postoperatively. Adverse events were limited to a transient weakness in one patient. We conclude that pallidotomy is a safe and effective treatment in medically refractory cases of generalized dystonia.

Original languageEnglish (US)
Pages (from-to)693-698
Number of pages6
JournalMovement Disorders
Issue number4
StatePublished - Jan 1 1998


  • Dystonia
  • Pallidotomy
  • Stereotactic surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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