P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Sachiyo Okayama; Levy Kopelovich; Gabriel Balmus; Robert S. Weiss; Brittney Shea Herbert; Andrew J. Dannenberg; Kotha Subbaramaiah

doi:10.1074/jbc.M113.532523

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Sachiyo Okayama, Levy Kopelovich, Gabriel Balmus, Robert S. Weiss, Brittney Shea Herbert, Andrew J. Dannenberg, Kotha Subbaramaiah

Academic Institute

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

Original language	English (US)
Pages (from-to)	6513-6525
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	10
DOIs	https://doi.org/10.1074/jbc.M113.532523
State	Published - Mar 7 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.532523

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title = "P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression",

abstract = "Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.",

author = "Sachiyo Okayama and Levy Kopelovich and Gabriel Balmus and Weiss, \{Robert S.\} and Herbert, \{Brittney Shea\} and Dannenberg, \{Andrew J.\} and Kotha Subbaramaiah",

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T1 - P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

AU - Okayama, Sachiyo

AU - Kopelovich, Levy

AU - Balmus, Gabriel

AU - Weiss, Robert S.

AU - Herbert, Brittney Shea

AU - Dannenberg, Andrew J.

AU - Subbaramaiah, Kotha

PY - 2014/3/7

Y1 - 2014/3/7

N2 - Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

AB - Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 10

ER -

P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Abstract

ASJC Scopus subject areas

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