TY - JOUR
T1 - P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression
AU - Okayama, Sachiyo
AU - Kopelovich, Levy
AU - Balmus, Gabriel
AU - Weiss, Robert S.
AU - Herbert, Brittney Shea
AU - Dannenberg, Andrew J.
AU - Subbaramaiah, Kotha
PY - 2014/3/7
Y1 - 2014/3/7
N2 - Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.
AB - Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.
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U2 - 10.1074/jbc.M113.532523
DO - 10.1074/jbc.M113.532523
M3 - Article
C2 - 24451373
AN - SCOPUS:84896799669
VL - 289
SP - 6513
EP - 6525
JO - The Journal of biological chemistry
JF - The Journal of biological chemistry
SN - 0021-9258
IS - 10
ER -