P53 protein regulates Hsp90 atpase activity and thereby wnt signaling by modulating Aha1 expression

Sachiyo Okayama, Levy Kopelovich, Gabriel Balmus, Robert S. Weiss, Brittney Shea Herbert, Andrew J. Dannenberg, Kotha Subbaramaiah

    Research output: Contribution to journalArticlepeer-review

    31 Scopus citations

    Abstract

    Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53 modulates Hsp90 ATPase activity via effects on Aha1 leading to changes in the expression of Wnt target genes. Conclusion: p53 regulates Hsp90 ATPase activity and thereby Wnt signaling. Significance: We describe a new mechanism by which p53 affects Wnt signaling.

    Original languageEnglish (US)
    Pages (from-to)6513-6525
    Number of pages13
    JournalJournal of Biological Chemistry
    Volume289
    Issue number10
    DOIs
    StatePublished - Mar 7 2014

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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