TY - JOUR
T1 - p53 protein accumulation is a specific marker of malignant potential in Barrett's metaplasia
AU - Younes, Mamoun
AU - Ertan, Atilla
AU - Lechago, Lia V.
AU - Somoano, Jacqueline R.
AU - Lechago, Juan
N1 - Funding Information:
Manuscript received July 10, 1996; revised manuscript received November 7, 1996; accepted December 17, 1996. From the Department of Pathology, and Gastroenterology Division, Department of Medicine, Baylor College of Medicine and the Methodist Hospital, Houston, Texas 77030. Supported in part by the Methodist Hospital Foundation Presented in part at the annual meeting of the American College ofGastroenterology,October21± 23,1996,Seattle,Washington. Address for reprint requests: Dr. Mamoun Younes, Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997
Y1 - 1997
N2 - Our aim was to determine the sensitivity and specificity of p53 accumulation as a marker of malignant potential in Barrett's metaplasia (BM). One hundred eighty biopsies from 61 patients with BM were evaluated for p53 accumulation by immunohistochemistry. Of 25 patients with LGD, 9 had p53-positive biopsies, and of these 5 (56%) developed HGD/CA, whereas 16 had p53-negative biopsies and none (0%) developed HGD/CA after similar follow-up times (P = 0.0108). As a marker of malignant potential in BM, p53 accumulation has a sensitivity of 100%, specificity of 93%, and a predictive value of a positive test of 0.56, compared to sensitivity of 100%, specificity of 64%, and predictive value of a positive test of 0.2 for a histologic diagnosis of LGD. We conclude that: (1) p53 accumulation is more specific and has better predictive value for subsequent development of HGD/CA than histologic diagnosis of LGD. (2) Patients with LGD and p53-positive biopsies are more likely to develop HGD/CA; therefore, they should be followed up more closely than those with LGD and p53-negative biopsies.
AB - Our aim was to determine the sensitivity and specificity of p53 accumulation as a marker of malignant potential in Barrett's metaplasia (BM). One hundred eighty biopsies from 61 patients with BM were evaluated for p53 accumulation by immunohistochemistry. Of 25 patients with LGD, 9 had p53-positive biopsies, and of these 5 (56%) developed HGD/CA, whereas 16 had p53-negative biopsies and none (0%) developed HGD/CA after similar follow-up times (P = 0.0108). As a marker of malignant potential in BM, p53 accumulation has a sensitivity of 100%, specificity of 93%, and a predictive value of a positive test of 0.56, compared to sensitivity of 100%, specificity of 64%, and predictive value of a positive test of 0.2 for a histologic diagnosis of LGD. We conclude that: (1) p53 accumulation is more specific and has better predictive value for subsequent development of HGD/CA than histologic diagnosis of LGD. (2) Patients with LGD and p53-positive biopsies are more likely to develop HGD/CA; therefore, they should be followed up more closely than those with LGD and p53-negative biopsies.
KW - adenocarcinoma
KW - Barrett's esophagus
KW - dysplasia
KW - immunohistochemistry
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=0031003486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031003486&partnerID=8YFLogxK
U2 - 10.1023/A:1018828207371
DO - 10.1023/A:1018828207371
M3 - Article
C2 - 9125634
AN - SCOPUS:0031003486
SN - 0163-2116
VL - 42
SP - 697
EP - 701
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 4
ER -