P3a amplitude predicts successful treatment program completion in substance-dependent individuals

Nathaniel E. Anderson, Robyn M. Baldridge, Matthew S. Stanford

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


This study examined P3a amplitude as a direct predictor of treatment success for substance dependence. Participants were 35 adults (27 men, 8 women) undergoing treatment for substance dependence at an urban residential treatment facility between October 2005 and July 2007. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria were used to confirm substance dependence. P3a amplitude was significantly smaller for those who dropped out of treatment. Discriminant function analysis confirmed that P3a amplitude was a robust predictor of treatment completion, more sensitive than other measures including substance abuse severity. Implications for the interpretation of P3a amplitude as an index of executive function are discussed.

Original languageEnglish (US)
Pages (from-to)669-677
Number of pages9
JournalSubstance Use and Misuse
Issue number5
StatePublished - Mar 15 2011


  • P300
  • P3a
  • event-related potentials
  • substance abuse
  • treatment success

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health(social science)
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health


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