p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes

Munir Shahjahan, Cherie H. Dunphy, April Ewton, Youli Zu, Federico A. Monzon, Lawrence Rice, Chung Che Chang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The goal of the present study was to evaluate the activation patterns of p38 mitogen-activated protein kinase (MAPK) in myeloproliferative disorders (MPDs) and myelodysplastic syndromes (MDSs). Phosphorylated (activated) p38 MAPK was analyzed immunohistochemically in formalin-fixed decalcified bone marrow core biopsy specimens from 32 MPD, 33 MDS, and 11 control cases. Moderate p38 activation was commonly seen in MDS, whereas weak p38 activation was seen in all MPD cases and all control cases but 1 in the erythroid lineage. In myeloid and megakaryocytic lineages, strong p38 activation was more commonly observed in MDS compared with MPD (myeloid, 22/33 vs 2/32; P < .0001; megakaryocytic, 18/23 vs 5/32; P < .0001) and control (myeloid, 22/33 vs 2/11; P = .012; megakaryocytic, 18/23 vs 3/9; P = .035) cases. Furthermore, weak p38 activation was observed in myeloid and megakaryocytic lineages in MPD compared with control (myeloid, 15/32 vs 1/11; P = .033; megakaryocytic, 16/32 vs 0/9; P = .007) cases. Increased p38 MAPK activation may have a role in inhibiting hematopoiesis leading to cytopenias in MDS, and relatively decreased p38 activation in MPD might promote hematopoiesis, resulting in cytosis.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume130
Issue number4
DOIs
StatePublished - Oct 2008

Keywords

  • Myelodysplastic syndrome
  • Myeloproliferative disorder
  • p38 mitogen-activated protein kinase

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes'. Together they form a unique fingerprint.

Cite this