Oxidative stress in heroin administered mice and natural antioxidants protection

Jing Pan; Qi Zhang; Yuntao Zhang; Zhuqing Ouyang; Qiusheng Zheng; Rongliang Zheng

doi:10.1016/j.lfs.2004.12.025

Oxidative stress in heroin administered mice and natural antioxidants protection

Jing Pan, Qi Zhang, Yuntao Zhang, Zhuqing Ouyang, Qiusheng Zheng, Rongliang Zheng

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The oxidative stress of heroin administered mice via intraperitoneal injection, and the therapeutic effects of exogenous antioxidants on the restrain of the oxidative damage of biomolecules and withdrawal syndrome were studied. After administered with heroin, mice showed decrease of total antioxidant capacity in blood, increase of reactive oxygen species production in white blood cells, and increase of oxidative damages of protein and lipid in brain and liver, but not in heart. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome.

Original language	English (US)
Pages (from-to)	183-193
Number of pages	11
Journal	Life sciences
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/j.lfs.2004.12.025
State	Published - May 27 2005

Keywords

Antioxidant
Heroin addiction
Oxidative stress
Withdrawal syndrome

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/j.lfs.2004.12.025

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title = "Oxidative stress in heroin administered mice and natural antioxidants protection",

abstract = "The oxidative stress of heroin administered mice via intraperitoneal injection, and the therapeutic effects of exogenous antioxidants on the restrain of the oxidative damage of biomolecules and withdrawal syndrome were studied. After administered with heroin, mice showed decrease of total antioxidant capacity in blood, increase of reactive oxygen species production in white blood cells, and increase of oxidative damages of protein and lipid in brain and liver, but not in heart. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome.",

keywords = "Antioxidant, Heroin addiction, Oxidative stress, Withdrawal syndrome",

author = "Jing Pan and Qi Zhang and Yuntao Zhang and Zhuqing Ouyang and Qiusheng Zheng and Rongliang Zheng",

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AU - Pan, Jing

AU - Zhang, Qi

AU - Zhang, Yuntao

AU - Ouyang, Zhuqing

AU - Zheng, Qiusheng

AU - Zheng, Rongliang

PY - 2005/5/27

Y1 - 2005/5/27

N2 - The oxidative stress of heroin administered mice via intraperitoneal injection, and the therapeutic effects of exogenous antioxidants on the restrain of the oxidative damage of biomolecules and withdrawal syndrome were studied. After administered with heroin, mice showed decrease of total antioxidant capacity in blood, increase of reactive oxygen species production in white blood cells, and increase of oxidative damages of protein and lipid in brain and liver, but not in heart. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome.

AB - The oxidative stress of heroin administered mice via intraperitoneal injection, and the therapeutic effects of exogenous antioxidants on the restrain of the oxidative damage of biomolecules and withdrawal syndrome were studied. After administered with heroin, mice showed decrease of total antioxidant capacity in blood, increase of reactive oxygen species production in white blood cells, and increase of oxidative damages of protein and lipid in brain and liver, but not in heart. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal syndrome.

KW - Antioxidant

KW - Heroin addiction

KW - Oxidative stress

KW - Withdrawal syndrome

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Oxidative stress in heroin administered mice and natural antioxidants protection

Abstract

Keywords

ASJC Scopus subject areas

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