Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer

Huayue Lin, Wenjuan Liu, Zanxi Fang, Xianming Liang, Juan Li, Yongying Bai, Lingqing Lin, Hanyu You, Yihua Pei, Fen Wang, Zhong Ying Zhang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration, and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of WISP1, MMP7 and VEGFA in the Wnt pathway, and anti-apoptotic gene BCL2 and CA9, however, elevated expression of pro-apoptotic gene ACSL5. The findings suggested that overexpressed DHX32 played an important role in CRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a novel therapeutic target for CRC.

Original languageEnglish (US)
Article number9247
JournalScientific Reports
Volume5
DOIs
StatePublished - Mar 18 2015
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer'. Together they form a unique fingerprint.

Cite this