Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma

Carsten G. Häckel, Sabine Krueger, Hans Jürgen Grote, Yumi Oshiro, Sherie Hodges, Dennis A. Johnston, Mark E. Johnson, Albert Roessner, Alberto G. Ayala, Bogdan Czerniak

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

BACKGROUND. Deregulation of the cellular protease network has been shown to be responsible for aggressive clinical behavior in several common human malignancies. In the current study, the authors evaluated the expression patterns of proteases in patients with chondrosarcoma of bone and correlated these patterns with clinical outcome. METHODS. The expression levels of urokinase plasminogen activator; matrix metallo-proteinase types-1, -2, and -9; and cathepsins B and L were determined immunohistochemically in 114 cases of chondrosarcomas of bone and were correlated with their clinicopathologic parameters as well as with long term follow-up data. RESULTS. Overexpression of cathepsin B was associated with a high rate of local recurrence (P = 0.006) and a decreased recurrence free survival (P = 0.005). Overexpression of urokinase plasminogen activator was associated with an increased rate of metastasis (P = 0.013), a decreased metastasis free survival (P = 0.016), and a decreased 5-year overall survival rate (P = 0.048). The univariate Cox model showed that tumor extension into soft tissue, high histologic grade, and overexpression of cathepsin B were predictors of adverse outcome. Multivariate analysis showed only overexpression of cathepsin B and tumor extension into soft tissue to be independent predictors of local recurrence. CONCLUSIONS. Overexpression of cathepsin B and urokinase plasminogen activator can be used to identify those patients with chondrosarcoma of bone who have an increased risk of local recurrence and distant metastases. (C) 2000 American Cancer Society.

Original languageEnglish (US)
Pages (from-to)995-1003
Number of pages9
JournalCancer
Volume89
Issue number5
DOIs
StatePublished - Sep 1 2000

Keywords

  • Cellular proteases
  • Chondrosarcoma
  • Immunohistochemistry
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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