Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells

Keyphrases

• Adaptor Molecule 9%
• Apaf-1 100%
• Apoptosis 45%
• Apoptotic Thresholds 9%
• B-cell Lymphoma 2 (Bcl-2) 18%
• Bcl-xL 18%
• Caspase Inhibitor 9%
• Caspase-3 18%
• Caspase-9 27%
• Cleavage Activity 9%
• Co-expression 9%
• Cytochrome c (Cyt c) 9%
• DFF45 9%
• Dominant-negative mutant 9%
• Etoposide 100%
• Fas Ligand 9%
• Fold Increase 9%
• High-level Expression 9%
• HL-60 Cells 100%
• Human Leukemia HL-60 Cells 9%
• Induced Apoptosis 18%
• Intracellular Level 9%
• Molecular Determinants 9%
• Myeloid Leukemia 9%
• Non-associated 9%
• Overexpressing 18%
• Overexpression 100%
• Paclitaxel 100%
• Poly(ADP-ribose) Polymerase 9%
• Procaspase-9 9%
• Promote Apoptosis 100%
• Stable Transfection 9%
• Transfectant 9%
• Transient Overexpression 9%
• Transient Transfection 9%
• Z-VAD-FMK 9%

Neuroscience

• Bcl-2 25%
• Caspase 12%
• Caspase 3 25%
• Caspase-9 37%
• Cytochrome C 12%
• Etoposide 100%
• Fas Ligand 12%
• Myeloid 12%
• Paclitaxel 100%
• Poly ADP Ribose Polymerase 12%
• Procaspase 9 12%
• Programmed Cell Death 100%
• Stable Transfection 12%
• Transient Transfection 12%
• XIAP 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Caspase 3 50%
• Caspase 9 75%
• Caspase Inhibitor 25%
• Cytochrome C 25%
• Etoposide 100%
• Fas Ligand 25%
• Myeloid Leukemia 25%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 25%
• Paclitaxel 100%
• Procaspase 9 25%