@article{996d37fcc5db4e178d1592743acbb2e3,
title = "Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma",
abstract = "Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.",
keywords = "T2, larynx, outcomes, radiotherapy, survival",
author = "{Al Feghali}, {Karine A.} and Youssef, {Bassem Y.} and Mohamed, {Abdallah S.R.} and Lara Hilal and Smith, {Blaine D.} and Ibrahim Abu-Gheida and Georges Farha and Gunn, {G. Brandon} and Jack Phan and Jan Lewin and Apurva Thekdi and Morrison, {William H.} and Garden, {Adam S.} and Fuller, {Clifton David} and Rosenthal, {David I.}",
note = "Funding Information: C. D. F. received funding and salary support related to this project from the National Institutes of Health (NIH), including: the National Institute for Dental and Craniofacial Research (NIDCR) Academic Industrial Partnership Grant (R01DE028290); National Cancer Institute (NCI) Early Phase Clinical Trials in Imaging and Image‐Guided Interventions Program (1R01CA218148); an NIH/NCI Cancer Center Support Grant (CCSG) Pilot Research Program Award from the UT MD Anderson CCSG Radiation Oncology and Cancer Imaging Program (P30CA016672) and an NIH/NCI Head and Neck Specialized Programs of Research Excellence (SPORE) Developmental Research Program Award (P50CA097007). Funding Information: C. D. F. received funding and salary support unrelated to this project from: the NIDCR Establishing Outcome Measures Award (1R01DE025248/R56DE025248) and National Science Foundation (NSF), Division of Mathematical Sciences, Joint NIH/NSF Initiative on Quantitative Approaches to Biomedical Big Data (QuBBD) Grant (NSF 1557679); NSF Division of Civil, Mechanical, and Manufacturing Innovation (CMMI) standard grant (NSF 1933369) a National Institute of Biomedical Imaging and Bioengineering (NIBIB) Research Education Programs for Residents and Clinical Fellows Grant (R25EB025787‐01); the NIH Big Data to Knowledge (BD2K) Program of the NCI Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science Award (1R01CA214825), and the MD Anderson Sister Institution Network Fund. Funding Information: Direct infrastructure support was provided by the multidisciplinary Stiefel Oropharyngeal Research Fund of the University of Texas MD Anderson Cancer Center Charles and Daneen Stiefel Center for Head and Neck Cancer and the Cancer Center Support Grant (P30CA016672) and the MD Anderson Program in Image‐guided Cancer Therapy. Funding Information: C. D. F. has received direct industry grant support, honoraria, and travel funding from Elekta AB. None of these fundings constitute conflicts of interest with this project. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals, Inc.",
year = "2020",
month = oct,
day = "1",
doi = "10.1002/hed.26308",
language = "English (US)",
volume = "42",
pages = "2791--2800",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley",
number = "10",
}