Background: We report outcomes for patients with T2N0M0 glottic squamous cell carcinoma (SCC) treated with radiation therapy (RT). Methods: Patients who received definitive RT for T2 glottic SCC from 2000 through 2013 were retrospectively reviewed. Results: One hundred and thirteen patients were analyzed (median follow-up time 91 months; 85 patients received three-dimensional conformal radiotherapy [3D-CRT] and 28 received intensity-modulated radiation therapy [IMRT]). Fractionation was conventional (58%) or altered (42%); 20 patients (18%) received concurrent chemotherapy. Five-year local control was 83% for the 3D-CRT vs 81% for the IMRT group (P =.76). The ultimate locoregional control at 5 years was 100% for IMRT vs 91% for 3D-CRT (P =.1). The 5-year overall survival (OS) was 78% for 3D-CRT vs 81% for IMRT (P =.83). On multivariate analysis, younger age was the only independent predictor of improved OS (P =.0002). Conclusions: Oncologic and survival outcomes were excellent for patients with T2N0 glottic cancer. Patients treated with IMRT and 3D-CRT had no statistically significant differences in all investigated endpoints.
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