Outcomes after lung resection in renal transplant patients with pulmonary mucormycosis

Abhinav Seth, Shivakumar S. Patil, David Axelrod, Harkant Singh, Ashish Sharma, Deepesh Benjamin Kenwar, Kim Vaiphei, Milind Mandwar, Sahil Rally, Sarbpreet Singh

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Pulmonary mucormycosis has been associated with high mortality (reported up to 100%) in renal transplant recipients. Methods: This was a retrospective analysis of renal transplant patients with pulmonary mucormycosis between April 2014 and March 2020, who underwent surgical resection of the affected lung along with liposomal amphotericin therapy. Patients with lower respiratory illness features underwent chest X-ray, high-resolution computed tomography of the chest, and those with suspicious findings underwent analysis of bronchioloalveolar fluid and transbronchial lung biopsy. Patients with histological or microbiological evidence of mucormycosis were started on liposomal Amphotericin B. Tacrolimus and mycophenolate mofetil were stopped at the time of diagnosis. Result: Ten patients underwent combined management, while five patients were managed medically. At last follow up, seven out of ten patients (70%) who underwent combined management and two of the five patients (40%) who were managed medically, had a mean survival of 28.86 months (sd = 15.71, median = 25) and 14.17 months (sd = 12.21, median = 18), respectively, post-diagnosis of pulmonary mucormycosis. Conclusion: Surgical resection combined with antifungals in the perioperative period and decreased immunosuppression may improve the outcomes in renal transplant patients with pulmonary mucormycosis.

Original languageEnglish (US)
Article numbere14689
JournalClinical Transplantation
Issue number7
StatePublished - Jul 2022


  • amphotericin
  • graft and patient survival outcomes
  • pulmonary mucormycosis
  • renal transplant patients
  • surgical resection

ASJC Scopus subject areas

  • Transplantation


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