Outcome of HCV genotype 1 treatment in HIV-coinfected patients with chronic kidney disease

Chronic renal insufficiency is a barrier for the treatment of hepatitis C virus (HCV), and yet virus clearance is desirable prior to kidney transplantation. Several reports document success of kidney transplantation in the setting of HIV infection. We analyzed the treatment outcome of patients with HIV and HCV genotype 1 infections and chronic kidney disease, who received pegylated interferon with or without ribavirin in our center. Of the 7 patients, 2 achieved sustained virological response. None of the responders had end-stage renal disease, suggesting that HCV treatment is most likely to be successful in earlier stages of renal disease.