Osteosarcoma: Specimen management following primary chemotherapy

A. K. Raymond, W. Simms, A. G. Ayala

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The use of preoperative (i.e., primary) chemotherapy has been shown to be of direct and significant benefit to the osteosarcoma patient. There is virtually an immediate palliation of symptoms. Increasing numbers of patients with osteosarcoma involving bones of the appendicular skeleton are eligible for limb-salvage procedures secondary to the local effects of chemotherapy that result in a decrease in size and compaction (i.e., down-staging) of the tumors.

Original languageEnglish (US)
Pages (from-to)841-867
Number of pages27
JournalHematology/Oncology Clinics of North America
Issue number4
StatePublished - 1995

ASJC Scopus subject areas

  • Hematology
  • Oncology


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