Osteosarcoma: Intra‐arterial treatment of the primary tumor with cis‐diammine‐dichloroplatinum II (CDP): Angiographic, pathologic, and pharmacologic studies

Norman Jaffe, John Knapp, Vincent P. Chuang, Sidney Wallace, Alberto Ayala, John Murray, Ayten Cangir, Alexander Wang, Robert S. Benjamin

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Intra-arterial CDP was utilized to treat the primary tumor in 11 pediatric patients with osteosarcoma and in one with malignant fibrous histiocytoma. The investigation commenced with a phase I-II pilot study in four osteosarcoma patients. A dose of 150 mg/m 2 was found to be safe and effective in producing a clinical response. This was followed by a definitive study in the remaining seven osteosarcoma patients and in the one malignant fibrous histiocytoma patient. The results were assessed by specific clinical, pharmacologic, radiographic and pathologic criteria. The overall response in the definitive study was 50% with two patients exhibiting total tumor destruction. The success of intra-arterial CDP was attributed to its ability to achieve high local drug concentration and tumor penetration. This was demonstrated by pharmacologic studies.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalCancer
Volume51
Issue number3
DOIs
StatePublished - Feb 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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