Osteopontin in cardiovascular disease: A potential therapeutic target

Alfonso H. Waller, Monica Sanchez Shields, Edo Kaluski, Marc Klapholz

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalCardiology in review
Volume18
Issue number3
DOIs
StatePublished - May 1 2010

Keywords

  • Calcification
  • Heart failure
  • Myocardial infarction
  • Myocardial remodeling
  • Osteopontin
  • Valvular disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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