TY - JOUR
T1 - Osteopontin in cardiovascular disease
T2 - A potential therapeutic target
AU - Waller, Alfonso H.
AU - Shields, Monica Sanchez
AU - Kaluski, Edo
AU - Klapholz, Marc
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.
AB - Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.
KW - Calcification
KW - Heart failure
KW - Myocardial infarction
KW - Myocardial remodeling
KW - Osteopontin
KW - Valvular disease
UR - http://www.scopus.com/inward/record.url?scp=77951483204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951483204&partnerID=8YFLogxK
U2 - 10.1097/CRD.0b013e3181cfb646
DO - 10.1097/CRD.0b013e3181cfb646
M3 - Review article
C2 - 20395697
AN - SCOPUS:77951483204
SN - 1061-5377
VL - 18
SP - 125
EP - 131
JO - Cardiology in review
JF - Cardiology in review
IS - 3
ER -