TY - JOUR
T1 - Osteogenic protein-1 associated with mesenchymal stem cells promote bone allograft integration
AU - Di Bella, Claudia
AU - Aldini, Nicolò Nicoli
AU - Lucarelli, Enrico
AU - Dozza, Barbara
AU - Frisoni, Tommaso
AU - Martini, Lucia
AU - Fini, Milena
AU - Donati, Davide
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Limited incorporation and modest bone remodeling can cause allograft failure. We investigated whether mesenchymal stem cells (MSCs) and osteogenic protein-1 (OP-1) can improve allograft integration. A 3-cm full-size intercalary bone defect was created in the mid-diaphysis of the metatarsal bone of the sheep and it was replaced with an allograft alone (control group), or with MSCs (MSC group), OP-1 (OP-1 group), or MSCs and OP-1 (MSC+OP-1 group). Radiographic results showed a faster and complete integration of the allograft in the MSC+OP-1 group. Histology demonstrated that the amount of new bone was significantly greater inside the graft and a longer vessel penetration in the MSC+OP-1 group than in others. Mechanical strength of the allograft was not compromised by the high rate of bone remodeling. These results demonstrated that the association of MSCs and OP-1 improve bone allograft integration promoting an almost complete bone restoring.
AB - Limited incorporation and modest bone remodeling can cause allograft failure. We investigated whether mesenchymal stem cells (MSCs) and osteogenic protein-1 (OP-1) can improve allograft integration. A 3-cm full-size intercalary bone defect was created in the mid-diaphysis of the metatarsal bone of the sheep and it was replaced with an allograft alone (control group), or with MSCs (MSC group), OP-1 (OP-1 group), or MSCs and OP-1 (MSC+OP-1 group). Radiographic results showed a faster and complete integration of the allograft in the MSC+OP-1 group. Histology demonstrated that the amount of new bone was significantly greater inside the graft and a longer vessel penetration in the MSC+OP-1 group than in others. Mechanical strength of the allograft was not compromised by the high rate of bone remodeling. These results demonstrated that the association of MSCs and OP-1 improve bone allograft integration promoting an almost complete bone restoring.
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U2 - 10.1089/ten.tea.2009.0637
DO - 10.1089/ten.tea.2009.0637
M3 - Article
C2 - 20533882
AN - SCOPUS:77956081418
SN - 1937-3341
VL - 16
SP - 2967
EP - 2976
JO - Tissue Engineering - Part A
JF - Tissue Engineering - Part A
IS - 9
ER -