Osmotic pressures for binary solutions of non-electrolytes

Vladimir T. Granik; Bryan Ronain Smith; Stephen C. Lee; Mauro Ferrari

doi:10.1023/A:1020910407962

Osmotic pressures for binary solutions of non-electrolytes

Vladimir T. Granik, Bryan Ronain Smith, Stephen C. Lee, Mauro Ferrari

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A comprehensive new theory of osmotic pressure is mechanistically derived to be applicable to incompressible binary solutions of non-electrolytes independent of solute concentrations, membrane selectivity, solution ideality, and without recourse to adjustable parameters. The approach employed relies on Fick's diffusion laws, and introduces the concept of uncoupled aggregate diffusion. The theory is verified using direct and indirect experimental data of sucrose solutions and then compared to conventional osmotic pressure laws. Direct consequences of the new theory entail novel a priori expressions for the activity, activity coefficient, and chemical potential of solvent. Applications to drug delivery and biomolecular separation nanotechnology are discussed.

Original language	English (US)
Pages (from-to)	309-321
Number of pages	13
Journal	Biomedical Microdevices
Volume	4
Issue number	4
DOIs	https://doi.org/10.1023/A:1020910407962
State	Published - Dec 2002

Keywords

Biomolecular separation
Nanopore membrane
Osmotic mechanism
Osmotic pressure

ASJC Scopus subject areas

Medicine (miscellaneous)
Genetics
General Neuroscience

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AU - Granik, Vladimir T.

AU - Smith, Bryan Ronain

AU - Lee, Stephen C.

AU - Ferrari, Mauro

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Y1 - 2002/12

N2 - A comprehensive new theory of osmotic pressure is mechanistically derived to be applicable to incompressible binary solutions of non-electrolytes independent of solute concentrations, membrane selectivity, solution ideality, and without recourse to adjustable parameters. The approach employed relies on Fick's diffusion laws, and introduces the concept of uncoupled aggregate diffusion. The theory is verified using direct and indirect experimental data of sucrose solutions and then compared to conventional osmotic pressure laws. Direct consequences of the new theory entail novel a priori expressions for the activity, activity coefficient, and chemical potential of solvent. Applications to drug delivery and biomolecular separation nanotechnology are discussed.

AB - A comprehensive new theory of osmotic pressure is mechanistically derived to be applicable to incompressible binary solutions of non-electrolytes independent of solute concentrations, membrane selectivity, solution ideality, and without recourse to adjustable parameters. The approach employed relies on Fick's diffusion laws, and introduces the concept of uncoupled aggregate diffusion. The theory is verified using direct and indirect experimental data of sucrose solutions and then compared to conventional osmotic pressure laws. Direct consequences of the new theory entail novel a priori expressions for the activity, activity coefficient, and chemical potential of solvent. Applications to drug delivery and biomolecular separation nanotechnology are discussed.

KW - Biomolecular separation

KW - Nanopore membrane

KW - Osmotic mechanism

KW - Osmotic pressure

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Osmotic pressures for binary solutions of non-electrolytes

Abstract

Keywords

ASJC Scopus subject areas

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