Orthotopic Liver Transplantation for Biliary Atresia: Evolution of Management

J. Michael Millis, John J. Brems, Jonathan R. Hiatt, Andrew S. Klein, Tatsuto Ashizawa, Kenneth P. Ramming, William J. Quinones Baldrich, Ronald W. Busuttil

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Forty-five patients with biliary atresia were accepted for orthotopic liver transplantation. Nine patients died awaiting transplantation, and 36 underwent transplantation. A portoenterostomy had been performed in 28 of these 36 patients, and its presence did not significantly affect the intraoperative blood loss (5.6 vs 4.1 blood volumes), the need for retransplantation (21% vs 12%), biliary complications (21% vs 12%), postoperative infections (36% vs 25%), or survival (82% vs 63%). These results indicate that early portoenterostomy is appropriate early therapy for biliary atresia; however, prompt referral to a liver transplant center for evaluation at the first sign of cholestasis is needed to attain optimal results for transplantation. Revisions of the portoenterostomy prior to transplantation did not improve the longevity of the procedure but did substantially increase complications and death after orthotopic liver transplantation.

Original languageEnglish (US)
Pages (from-to)1237-1239
Number of pages3
JournalArchives of Surgery
Issue number10
StatePublished - Oct 1988

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Orthotopic Liver Transplantation for Biliary Atresia: Evolution of Management'. Together they form a unique fingerprint.

Cite this