Orthognathic Surgical Treatment in a Patient With Hyperimmunoglobulin E Syndrome

Rami Dibbs, Anjali Raghuram, Michelle G. Roy, Matthew G. Kaufman, Laura A. Monson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Autosomal-dominant hyperimmunoglobulin E syndrome (HIES), or Job syndrome, is a rare, multisystem, primary immunodeficiency disorder. Additionally, patients may also suffer from connective tissue, dental, and bone malformations. While current management of HIES is directed at prophylactic antibiotics to prevent infections, there is limited work describing surgical considerations for these patients, particularly with respect to hardware placement. Here we report a case of a patient with HIES who underwent orthognathic surgery for maxillary advancement and mandibular setback to address his severe class III malocclusion. The patient's postoperative course was complicated by significant infection, requiring multiple operations and ultimately, hardware removal after bone healing. Although this patient ultimately had a good outcome, the role of orthognathic surgery with implant placement in patients with HIES should be approached with caution and careful consideration.

Original languageEnglish (US)
Pages (from-to)E251-E254
JournalJournal of Craniofacial Surgery
Issue number3
StatePublished - May 1 2020


  • Hyperimmunoglobulin E syndrome
  • immunodeficiency
  • infection
  • orthognathic surgery

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


Dive into the research topics of 'Orthognathic Surgical Treatment in a Patient With Hyperimmunoglobulin E Syndrome'. Together they form a unique fingerprint.

Cite this