Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia

Patrick J. Hunt; Jeel Mehta; Matthew R. Ehrenburg; Daniela P. Reyes-Capó; Chen Chen; Arthur Zieske; Yuli Zu; Patricia Chévez-Barrios; Michael T. Yen; Stephen C. Pflugfelder

doi:10.1097/IOP.0000000000002719

Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia

Patrick J. Hunt, Jeel Mehta, Matthew R. Ehrenburg, Daniela P. Reyes-Capó, Chen Chen, Arthur Zieske, Yuli Zu, Patricia Chévez-Barrios, Michael T. Yen, Stephen C. Pflugfelder

Research output: Contribution to journal › Article › peer-review

Abstract

A 74-year-old man with a history of chronic lymphocytic leukemia (CLL) presented with large salmon-colored patch lesions along the inferior fornix and superotemporal conjunctiva of the OS. The patient underwent an incisional biopsy of the lesions, which showed a CLL with areas of large B-cell lymphoma, consistent with Richter transformation. Following medical and radiation-based therapy of these lesions, the patient returned 3 months later with inferomedial preseptal swelling in the contralateral eye, which biopsy proved to be recurrent/resistant low-grade CLL with a posttreatment extranodal marginal zone B-cell lymphoma pattern. This case exemplifies a rare presentation of CLL with Richter transformation and a recurrent/resistant posttreatment orbital CLL with a marginal zone B-cell lymphoma-like pattern.

Original language	English (US)
Pages (from-to)	e205-e209
Journal	Ophthalmic Plastic and Reconstructive Surgery
Volume	40
Issue number	6
DOIs	https://doi.org/10.1097/IOP.0000000000002719
State	Published - Nov 1 2024

ASJC Scopus subject areas

Surgery
Ophthalmology

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Hunt, P. J., Mehta, J., Ehrenburg, M. R., Reyes-Capó, D. P., Chen, C., Zieske, A., Zu, Y., Chévez-Barrios, P., Yen, M. T., & Pflugfelder, S. C. (2024). Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia. Ophthalmic Plastic and Reconstructive Surgery, 40(6), e205-e209. https://doi.org/10.1097/IOP.0000000000002719

Hunt, PJ, Mehta, J, Ehrenburg, MR, Reyes-Capó, DP, Chen, C, Zieske, A, Zu, Y, Chévez-Barrios, P, Yen, MT & Pflugfelder, SC 2024, 'Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia', Ophthalmic Plastic and Reconstructive Surgery, vol. 40, no. 6, pp. e205-e209. https://doi.org/10.1097/IOP.0000000000002719

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title = "Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia",

abstract = "A 74-year-old man with a history of chronic lymphocytic leukemia (CLL) presented with large salmon-colored patch lesions along the inferior fornix and superotemporal conjunctiva of the OS. The patient underwent an incisional biopsy of the lesions, which showed a CLL with areas of large B-cell lymphoma, consistent with Richter transformation. Following medical and radiation-based therapy of these lesions, the patient returned 3 months later with inferomedial preseptal swelling in the contralateral eye, which biopsy proved to be recurrent/resistant low-grade CLL with a posttreatment extranodal marginal zone B-cell lymphoma pattern. This case exemplifies a rare presentation of CLL with Richter transformation and a recurrent/resistant posttreatment orbital CLL with a marginal zone B-cell lymphoma-like pattern.",

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AU - Reyes-Capó, Daniela P.

AU - Chen, Chen

AU - Zieske, Arthur

AU - Zu, Yuli

AU - Chévez-Barrios, Patricia

AU - Yen, Michael T.

AU - Pflugfelder, Stephen C.

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AB - A 74-year-old man with a history of chronic lymphocytic leukemia (CLL) presented with large salmon-colored patch lesions along the inferior fornix and superotemporal conjunctiva of the OS. The patient underwent an incisional biopsy of the lesions, which showed a CLL with areas of large B-cell lymphoma, consistent with Richter transformation. Following medical and radiation-based therapy of these lesions, the patient returned 3 months later with inferomedial preseptal swelling in the contralateral eye, which biopsy proved to be recurrent/resistant low-grade CLL with a posttreatment extranodal marginal zone B-cell lymphoma pattern. This case exemplifies a rare presentation of CLL with Richter transformation and a recurrent/resistant posttreatment orbital CLL with a marginal zone B-cell lymphoma-like pattern.

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Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia

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