TY - JOUR
T1 - Orbital Richter Transformation With Subsequent Orbital MALT-type Lymphoma in a Patient With Chronic Lymphocytic Leukemia
AU - Hunt, Patrick J.
AU - Mehta, Jeel
AU - Ehrenburg, Matthew R.
AU - Reyes-Capó, Daniela P.
AU - Chen, Chen
AU - Zieske, Arthur
AU - Zu, Yuli
AU - Chévez-Barrios, Patricia
AU - Yen, Michael T.
AU - Pflugfelder, Stephen C.
N1 - Publisher Copyright:
© 2024 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
PY - 2024/11/1
Y1 - 2024/11/1
N2 - A 74-year-old man with a history of chronic lymphocytic leukemia (CLL) presented with large salmon-colored patch lesions along the inferior fornix and superotemporal conjunctiva of the OS. The patient underwent an incisional biopsy of the lesions, which showed a CLL with areas of large B-cell lymphoma, consistent with Richter transformation. Following medical and radiation-based therapy of these lesions, the patient returned 3 months later with inferomedial preseptal swelling in the contralateral eye, which biopsy proved to be recurrent/resistant low-grade CLL with a posttreatment extranodal marginal zone B-cell lymphoma pattern. This case exemplifies a rare presentation of CLL with Richter transformation and a recurrent/resistant posttreatment orbital CLL with a marginal zone B-cell lymphoma-like pattern.
AB - A 74-year-old man with a history of chronic lymphocytic leukemia (CLL) presented with large salmon-colored patch lesions along the inferior fornix and superotemporal conjunctiva of the OS. The patient underwent an incisional biopsy of the lesions, which showed a CLL with areas of large B-cell lymphoma, consistent with Richter transformation. Following medical and radiation-based therapy of these lesions, the patient returned 3 months later with inferomedial preseptal swelling in the contralateral eye, which biopsy proved to be recurrent/resistant low-grade CLL with a posttreatment extranodal marginal zone B-cell lymphoma pattern. This case exemplifies a rare presentation of CLL with Richter transformation and a recurrent/resistant posttreatment orbital CLL with a marginal zone B-cell lymphoma-like pattern.
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U2 - 10.1097/IOP.0000000000002719
DO - 10.1097/IOP.0000000000002719
M3 - Article
C2 - 39136940
AN - SCOPUS:85201381024
SN - 0740-9303
VL - 40
SP - e205-e209
JO - Ophthalmic Plastic and Reconstructive Surgery
JF - Ophthalmic Plastic and Reconstructive Surgery
IS - 6
ER -