Oral acyclovir for episodic treatment of recurrent genital herpes: Efficacy and safety

Leonard Harry Goldberg, Raymond Kaufman, Marcus A. Conant, Jay Sperber, Martha L. Allen, Mark Illeman, Sharon Chapman

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

This multicenter double-blind study of 157 patients was designed to evaluate the safety and efficacy of a new dosage regimen of oral acyclovir (800 mg twice a day for 5 days) for the treatment of recurrent genital herpes. The new regimen was compared with the standard dosage of 200 mg given five times a day to patients treated for three consecutive episodes (one episode with physician-initiated therapy and two with patient-initiated therapy) and followed up for three untreated episodes. The new regimen was well tolerated and effective. In male patients it may be more effective than the standard regimen of 200 mg given five times a day to treat vesicles that are already present.

Original languageEnglish (US)
Pages (from-to)256-264
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume15
Issue number2
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Dermatology

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