Optomicrofluidic Platforms for Rapid and Sensitive Detection of Biomarkers in Medical Diagnostics

Riccardo Funari, Rana M. Armaghan Ayaz, Claudio J. Oton, Amy Q. Shen, Fabrizio Di Pasquale

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optomicrofluidic sensing platforms, which integrate optical detection methods with microfluidic technology, have shown significant promise in laboratory settings. These platforms utilize functionalized optical transducers, such as plasmonic nanostructures or periodic gratings, for rapid and accurate detection of specific biological molecules. Here, we report on the design and application of optomicrofluidic platforms based on localized surface plasmon resonance (LSPR) with gold nanospikes and short-length long-period gratings (SL-LPG) in detecting and quantifying biomarkers like anti-SARS-CoV-2 antibodies and prostate cancer (PCa) biomarkers in real samples.

Original languageEnglish (US)
Title of host publicationFrontiers in Biological Detection
Subtitle of host publicationFrom Nanosensors to Systems XVII
EditorsAmos Danielli, Benjamin L. Miller, Sharon M. Weiss
PublisherSPIE
ISBN (Electronic)9781510684249
DOIs
StatePublished - 2025
EventFrontiers in Biological Detection: From Nanosensors to Systems XVII 2025 - San Francisco, United States
Duration: Jan 25 2025Jan 27 2025

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume13338
ISSN (Print)1605-7422

Conference

ConferenceFrontiers in Biological Detection: From Nanosensors to Systems XVII 2025
Country/TerritoryUnited States
CitySan Francisco
Period1/25/251/27/25

Keywords

  • Biomarker Detection
  • Biosensors
  • Localized Surface Plasmon Resonance
  • Optomicrofluidic Sensing Platforms
  • Prostate Cancer
  • SARS-CoV-2 Antibodies
  • Short-Length Long-Period Gratings

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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