Optogenetic probing of functional brain circuitry

James J. Mancuso, Jinsook Kim, Soojung Lee, Sachiko Tsuda, Nicholas B.H. Chow, George J. Augustine

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Recently developed optogenetic technologies offer the promise of high-speed mapping of brain circuitry. Genetically targeted light-gated channels and pumps, such as channelrhodopsins and halorhodopsin, allow optical control of neuronal activity with high spatial and temporal resolution. Optogenetic probes of neuronal activity, such as Clomeleon and Mermaid, allow light to be used to monitor the activity of a genetically defined population of neurons. Combining these two complementary sets of optogenetic probes will make it possible to perform all-optical circuit mapping. Owing to the improved efficiency and higher speed of data acquisition, this hybrid approach should enable high-throughput mapping of brain circuitry.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalExperimental Physiology
Issue number1
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)


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