Optogenetic Control of Voltage-Gated Calcium Channels

Guolin Ma, Jindou Liu, Yuepeng Ke, Xin Liu, Minyong Li, Fen Wang, Gang Han, Yun Huang, Youjun Wang, Yubin Zhou

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Voltage-gated Ca2+ (CaV) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV-mediated physiological processes.

Original languageEnglish (US)
Pages (from-to)7019-7022
Number of pages4
JournalAngewandte Chemie - International Edition
Volume57
Issue number24
DOIs
StatePublished - Jun 11 2018

Keywords

  • calcium signaling
  • ion channels
  • optogenetics
  • protein engineering
  • synthetic biology

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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