Optical sensing of macromolecules and microparticles distribution in tissues

K. V. Larin; S. Wang; P. Ruchhoeft; R. Willson; J. D. Morrisett; M. G. Ghosn

doi:10.1109/ICSENS.2012.6411079

Optical sensing of macromolecules and microparticles distribution in tissues

K. V. Larin, S. Wang, P. Ruchhoeft, R. Willson, J. D. Morrisett, M. G. Ghosn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

Original language	English (US)
Title of host publication	IEEE SENSORS 2012 - Proceedings
DOIs	https://doi.org/10.1109/ICSENS.2012.6411079
State	Published - Dec 1 2012
Event	11th IEEE SENSORS 2012 Conference - Taipei, Taiwan, Province of China Duration: Oct 28 2012 → Oct 31 2012

Other

Other	11th IEEE SENSORS 2012 Conference
Country/Territory	Taiwan, Province of China
City	Taipei
Period	10/28/12 → 10/31/12

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1109/ICSENS.2012.6411079

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title = "Optical sensing of macromolecules and microparticles distribution in tissues",

abstract = "This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.",

author = "Larin, {K. V.} and S. Wang and P. Ruchhoeft and R. Willson and Morrisett, {J. D.} and Ghosn, {M. G.}",

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AU - Larin, K. V.

AU - Wang, S.

AU - Ruchhoeft, P.

AU - Willson, R.

AU - Morrisett, J. D.

AU - Ghosn, M. G.

PY - 2012/12/1

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N2 - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

AB - This paper describe a highly systematic set of experiments demonstrating capability of Optical Coherence Tomography (OCT) technique for depth-resolved, real-time and truly noninvasive analysis of complex diffusion processes of macromolecules in epithelial and vascular tissues as well to image and detect magnetic microparticles (stationary and moving) under the skin with single-particle sensitivity. For example, we demonstrate that the permeation of VLDL, LDL, HDL, and glucose in normal and diseased human carotid endarterectomy tissues could be quantified that supported previous suggestions of an enhanced transport mechanism specific to LDL. Additionally, we investigated sensitivity of OCT to assess magnetic microbead (d=2.8 um) count under the skin, which could the basis for development of continuous glucose sensing platform.

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Optical sensing of macromolecules and microparticles distribution in tissues

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